Piece Of Puzzle Research Articles

Caregiver Mental Health: A Crucial Piece of the Recovery Puzzle

Caregiver Mental Health: A Crucial Piece of the Recovery Puzzle
 The role of a caregiver is multifaceted, encompassing physical, emotional, and sometimes financial responsibilities. Caregivers, whether family members or friends, find themselves navigating various emotions, uncertainties, and responsibilities. The stressors of caregiving and the emotional burden erode their own mental well-being, creating a silent crisis that is left out of the caregiver narrative.
 Studies reveal that caregivers grapple with anxiety, depression, and burnout. Poor mental health is well documented in the caregiving literature.
 One crucial avenue for support lies in psychoeducational programs tailored to caregivers. These initiatives offer practical tools to manage stress, enhance communication, and manage overall mental health. By equipping caregivers with knowledge, we empower them to navigate the challenges with greater understanding and confidence.
 Peer support networks represent another vital facet of caregiver well-being. Establishing communities where caregivers can share experiences, exchange coping strategies, and find solace in shared understanding is paramount. Breaking the isolation barrier can significantly alleviate the emotional burden on caregivers, creating a sense of belonging in a community that comprehends their unique struggles.
 Yet, the responsibility does not rest solely on caregivers and their communities. Institutions and policymakers must step forward to enact supportive measures. By addressing systemic barriers, we acknowledge the societal responsibility to nurture the mental health of those who selflessly nurture others.
 In nurturing the mental health of caregivers, we fortify the backbone of the recovery process, ensuring a more resilient, compassionate, and sustainable path forward.
  
  
  

Public health: a forgotten piece of the adaptation law puzzle

This paper uses the problem of extreme heat to illustrate the inadequacy of laws for protecting public health under climate change. Climate change is already having serious effects on public health. The Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment Report highlights significant adaptation gaps for human health protection, urging that public health adaptation must be ‘proactive, timely and effective’. The law can be a powerful tool for advancing adaptation to protect public health, but there has been very little scholarly analysis of its potential, or whether in some circumstances it may promote maladaptation. For example, legal regimes for land use planning typically respect existing uses of property and make retrofitting for climate-proofing hard to mandate. These regimes can take many years to amend so new infrastructure continues to comply with outdated approaches, such as relying on air conditioning for cooling and offering limited shading. Laws also promote a focus on crisis management during a heat event but fail to promote the preventive action necessary to foster resilience. We present a case study of how the law exacerbates public health risks from extreme heat and falls short of facilitating adaptation in the Greater Western Sydney region of Australia, an area with a population of 2.6 million. In 2019, this area experienced a record near-surface air temperature of 52°C (125.6°F) causing significant adverse physical and mental health impacts. The public health impacts of extreme temperatures in this region are well documented, as are the increasing strains on emergency and health services. This case study demonstrates that laws could help to control heat in the landscape and secure the safety of vulnerable populations, but to do so they must prioritize adaptation to the health impacts of climate change.

Patient safety culture: A missing puzzle piece in patient care in the nursing profession

Patient safety culture: A missing puzzle piece in patient care in the nursing profession

Utilizing CO2 as a strategy to scale up Direct Air Capture may face fewer short-term barriers than directly storing CO2

Abstract Direct Air Capture (DAC) is increasingly recognized as a necessary puzzle piece to achieve the Paris climate targets. However, the current high cost and energy intensity of DAC act as a barrier. Short-term strategies for initial deployment, technology improvement, and cost reduction are needed to enable large-scale deployment. We assess and compare two near-term pathways leading to the same installed DAC capacity and thus yielding the same cost reductions: its combination with CO2 storage as DACCS, or its deployment for CO2 utilization as DACCU e.g., for synthetic fuels, chemicals, and materials; we characterize these as Direct and Spillover pathways. Drawing on the Multi-level Perspective on Technological Transition as a heuristic, we examine both technical and immaterial factors needed to scale up DAC under the two pathways, in order to assess the pathways’ relative advantages and to identify possible short-term bottlenecks. We find neither pathway to be clearly better: the Direct pathway offers technical advantages but faces regulatory barriers that need to be resolved before deployment, while the Spillover pathway offers market and governance advantages but faces challenges related to hydrogen production and increasing resource needs as it scales up. There may be reasons for policymakers to therefore pursue both approaches in a dynamic manner. This could involve prioritizing the Spillover pathway in the short term due to possibly fewer short-term regulatory barriers and its ability to produce net-zero emission products for existing and accessible markets. Once short-term governance obstacles have been addressed, however, the Direct pathway may allow for more efficient scaling of DAC capacity and cost reductions, especially if by then the needed infrastructure and institutions are in place.

Technology Focus: Heavy Oil (April 2024)

Heavy oil can be one of the more technically challenging resources to recover. It is often easy to find but hard to move. This creates an incentive for knowledge seekers and problem solvers: The puzzle pieces are on the table; we just need to put them together. The physical characteristics of heavy oil and the formations in which it is found—the puzzle pieces—are often unique to a region or even to a specific asset, so recovery techniques must be tuned, adapted, and sometimes invented for each region. Creative professionals around the world are taking up this challenge and sharing their work with us in a wealth of excellent recent publications. In particular in our featured papers, we see three different parts of the world working with three different recovery techniques. First, we have a fundamental study in paper SPE 212779 of a perennial question from Canada’s oil sands: Where does the emulsion form in the steam-assisted gravity drainage (SAGD) recovery process, where the effect of a surfactant is studied? Moving south to paper SPE 213199, we review a study that progresses from laboratory work to field implementation using foam injection in Colombia in conjunction with cyclic steam stimulation. From Colombia, we look across to the other side of the world to paper SPE 215943, where we see a transition from steamflood recovery to an adapted configuration of SAGD, with a comprehensive discussion on optimizing production in Mukhaizna field in Oman. The theme of adaptation and invention continues in our recommended reading, with discussions of fundamental research, applied and practical insights on field implementation, and all the steps in between as these are applied to heavy oil production challenges around the world. I hope you enjoy the tour. Recommended additional reading at OnePetro: www.onepetro.org. SPE 212767 Part 1: Kinetics of Methane Exsolution From Bitumen in Thermal Recovery Processes—Experimental Study by Mohammad Khalifi, Imperial Oil Resources, et al. SPE 214113 Physical and Numerical Simulations of Offset Well Pair Combined Steam-Drive and Gravity-Drainage Process To Develop Superheavy Oil or Oil Sands Project by Guangyue Liang, China National Petroleum Corporation, et al. SPE 215342 Optimization of Chemical Acid Stimulation by Improving Selection Intervals in Lateral Section of Horizontal Well in X Field Heavy Oil Steamflood by Fatichin Fatichin, Pertamina, et al.

12C/13C of Kepler giant stars: The missing piece of the mixing puzzle

Context. Despite a rich observational background, few spectroscopic studies have dealt with the measurement of the carbon isotopic ratio in giant stars. However, it is a key element in understanding the mixing mechanisms that occur in the interiors of giant stars. Aims. We present the CNO and 12C/13C abundances derived for 71 giant field stars. Then, using this new catalogue and complementary data from the Kepler and Gaia satellites, we study the efficiency of mixing occurring in the giant branch as a function of the stellar properties of the stars (e.g. mass, age, metallicity). Methods. We determined the abundances of CNO and more specifically the carbon isotopic ratio using the high-resolution FIbre-fed Echelle Spectrograph on the Nordic Optical Telescope, for 71 giant field stars. In addition, asteroseismology from the Kepler satellite is available for all stars, providing the stellar masses, ages, and evolutionary states. Finally, astrometry from the Gaia data is also available for most of the sample. We compare these new determinations with stellar evolution models taking into account the effects of transport processes. To exploit the complete potential of our extensive catalogue, and considering both the Milky Way evolution and the impact of stellar evolution, we built mock catalogues using the Besançon Galaxy model in which stellar evolution models taking into account the effects of thermohaline instability are included. Results. We confirm that the carbon isotopic ratio at the surface of core He-burning stars is lower than that of first-ascent RGB stars. The carbon isotopic ratio measured at the surface of the core He-burning stars increases with [Fe/H] and stellar mass, while it decreases with stellar age. These trends are all nicely explained by the thermohaline mixing that occurs in red giants. We show that our models can explain the behaviour of 12C/13C versus N/O, although the observations seem to show a lower N/O than the models. We also note that more constraints on the thick disc core He-burning stars are needed to understand this difference. Conclusions. Overall, the current model including thermohaline mixing is able to reproduce very well the 12C/13C with the stellar metallicity and with the stellar mass and age.

Neglected puzzle pieces of urban green infrastructure: richness, cover, and composition of insect-pollinated plants in traffic-related green spaces

ContextIn cities, insect-pollinated vascular plants enhance environmental quality, support pollinators, and provide essential ecosystem services for citizens. However, floral communities associated with traffic-related green spaces are rarely considered valuable elements of urban green infrastructure (UGI).ObjectivesThe main objective of this work was to assess if traffic-related green spaces in Finland possess species-rich floral communities and can assist urban ecological restoration—converting degraded areas into functionally diverse ecosystems. Thus, we evaluated richness, cover, and community composition of insect-pollinated plants (emphasizing flowering ones) on traffic islands, parking lots, and road verges.MethodsThe assessment was performed during the mean flowering phenophase of insect-pollinated plants in the European boreal zone (July and August) using a standard quadrat (1 m2) placement method. We studied plants in urban and suburban locations of three highly populated (> 170 000 inhabitants) Finnish cities—Helsinki, Tampere, and Turku. There were 90 sampling sites with 15 replicates per location type in each city and five measurement replicates per green space (habitat) type. The species richness, cover, and composition were assessed in relation to location, habitat type, city, the average daily traffic (ADT), and distance to the road.ResultsUrban locations had lower total plant species richness and fewer indicator species (characterized only by a single indicator species) compared to suburban locations (characterized by five indicator species). Species richness of plants flowering during the time of the survey did not differ among locations. Traffic islands were richer habitats for flowering plants than road verges but did not differ from parking lots. Total vegetation cover and cover of insect-pollinated flowering plants increased with an increasing distance from the road. Vegetation cover differed among habitats being higher on road verges than on traffic islands irrespective of ADT. In all habitat types, the two most common flowering species were yarrow Achillea millefolium and autumn hawkbit Leontodon autumnalis which occurred at 70.2% and 67.8% of the sampling sites, respectively. However, the mean cover of the ten most common flowering species (when present) was low and varied between 1.5 and 9.5% per m2.ConclusionsSimilar richness of flowering plants (but not total plant species) in urban and suburban locations might indicate equal importance of ecosystem services provided by flowering plants in cities irrespective of location. Because traffic islands and parking lots contain rich plant communities, they should be better integrated into UGI and valued by city planners. Management intensity in terms of grass cuts should be ecologically justified. An increase in the number of insect-pollinated plant species in urban traffic-related green spaces might help to improve environmental quality in cities in terms of increasing pollinator biodiversity and reducing pollution.

AI Fuzzy Based Prediction and Prorogation of Alzheimer's Cancer

INTRODUCTION: Although decades of experimental and clinical research have shed a lot of light on the pathogenesis of Alzheimer's disease (AD), there are still a lot of questions that need to be answered. The current proliferation of open data-sharing initiatives that collect clinical, routine, and biological data from individuals with Alzheimer's disease presents a potentially boundless wealth of information about a condition.
 METHODS: While it is possible to hypothesize that there is no comprehensive collection of puzzle pieces, there is currently a proliferation of such initiatives. This abundance of data surpasses the cognitive capacity of humans to comprehend and interpret fully. In addition, the psychophysiology mechanisms underlying the whole biological continuum of AD may be investigated by combining Big Data collected from multi-omics studies. In this regard, Artificial Intelligence (AI) offers a robust toolbox for evaluating large, complex data sets, which might be used to gain a deeper understanding of AD. This review looks at the recent findings in the field of AD research and the possible obstacles that AI may face in the future.
 RESULTS: This research explores the use of CAD tools for diagnosing AD and the potential use of AI in healthcare settings. In particular, investigate the feasibility of using AI to stratify patients according to their risk of developing AD and to forecast which of these patients would benefit most from receiving personalized therapies.
 CONCLUSION: To improve these, fuzzy membership functions and rule bases, fuzzy models are trained using fuzzy logic and machine learning.

Lower Cretaceous holostratigraphy in Svalbard: the Arctic key piece of the Boreal basin puzzle

Abstract Lower Cretaceous stratigraphy of the high palaeo-latitude Arctic-Boreal Realm is generally more poorly understood than its lower-latitude Tethyan counterpart, prohibiting regional correlations and evaluation of global climate dynamics during this important high- p CO 2 period. In this paper, a holostratigraphic scheme and lithostratigraphic revision are presented for the Valanginian-lower Barremian, siliciclastic ramp succession of the Rurikfjellet Formation in Svalbard, drawn from synthesis of the latest published sedimentological, biostratigraphic, petrophysical, sequence stratigraphic, chemostratigraphic and chronostratigraphic results, supplemented by new measured sections from five localities. The offshore mudstone-dominated Wimanfjellet Member (Valanginian-lower Barremian) is retained, whereas three new members are defined according to their distinct geographic, sedimentological and stratigraphic characteristics: The Adventpynten Member (upper(?) Valanginian-lowermost upper Hauterivian) constitutes a thick, relatively localized succession of mass-transport deposits. The Kikutodden Member (Hauterivian-lower Barremian) is discarded and replaced by the northern Bohemanneset Member and southern Fotografryggen Member, representing respectively: heterogeneous prodelta to delta front deposits; and sandy offshore transition to shoreface deposits. The Rurikfjellet Formation records Valanginian-earliest late Hauterivian shoreline progradation followed by late Hauterivian-early Barremian shoreline retreat and flooding across a low-gradient ramp, which never experienced full regression into continental deposits within the extent of the present-day outcrop belt.

Finding pieces in the archaeal cell division puzzle.

Finding pieces in the archaeal cell division puzzle.

Missing Puzzle Pieces: Cleft Lip and Palate

Facial differences can arise while a baby is still growing inside the mother. Two common examples include cleft lip and cleft palate. Most of the body’s cells contain DNA, which serves as the instructions for creating all the features of the body, such as the parts of the face. Cells use DNA’s instructions to form the face from five big “puzzle pieces” called prominences. Sometimes the DNA instructions get changed or steps are skipped, which can change how the puzzle pieces, or prominences, connect. This results in facial differences like cleft lip, in which there is a gap in the lip and cleft palate, in which there is a gap in the roof of the mouth. Most cases of cleft lip and cleft palate can be fixed with surgery, and children go on to live long, healthy lives.

There Is Still a Need for a Comprehensive Investigation of the Health Consequences of Exposure to Urban Air with Special Regard to Particulate Matter (PM) and Cardiovascular Effects

Air pollution is a foremost public health problem worldwide. The pulmonary effects of air pollution have been well established for decades, and substantial epidemiological evidence is consistently showing that both acute and chronic exposure to air pollution is linked to cardiovascular morbidity and mortality. The underlying cause for this link is, however, still unknown, and many questions remain open. Most of the epidemiological studies focusing on health consequences of exposure to urban air used data from air monitoring stations or—when applying personal sampling or monitoring—measured a limited number of components to assess the exposure. On the other hand, studies conducting a decent exposure characterization and measuring a relatively large number of components with personal sampling had little or no focus on the effects and investigated only a few biomarkers. The number of research studies on this topic is huge, but at the same time, it seems as if there was no need for a comprehensive examination of the effects of urban air pollution on health. Researchers and research supporting organizations, in their fascination with the search for “novelty” and “beyond state-of-the-art”, do not seem to be aware of that they will never be able to assemble the whole picture from the puzzle pieces of research activities focusing only on certain aspects. Without a comprehensive investigation, we might never be able to answer such questions as (i) which of the urban air pollutants are forerunners in causing health effects, especially cardiovascular effects? (ii) Which biomarkers have the best predictor performance in early effects? (iii) Are there biomarkers or combinations of biomarkers that can help determine the degree of individual susceptibility and sensitivity and the dependence of these by different factors (e.g., age, gender, and physical activity)? The authors of this article aim to go through the already investigated—at the same time, essential—elements of the topic and propose a more comprehensive study, which, of course, can be expanded, debated, and improved.

Reply to Wostyn, P. Targeting the Cerebrospinal Fluid Compartment in Glaucoma: Still the Dark Side of the Moon? Comment on "Passaro et al. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle? J. Clin. Med. 2023, 12, 6900".

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The Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention.

New data suggest that the aggregation of misfolded native proteins initiates and drives the pathogenic cascade that leads to Alzheimer's disease (AD) and other age-related neurodegenerative disorders. We propose a unifying single toxin theory of brain neurodegeneration that identifies new targets and approaches to the development of disease-modifying treatments. An extensive body of genetic evidence suggests soluble aggregates of beta-amyloid (Aβ) as the primary neurotoxin in the pathogenesis of AD. New insights from fluid biomarkers, imaging, and clinical studies provide further evidence for the decisive impact of toxic Aβ species in the initiation and progression of AD. Understanding the distinct roles of soluble and insoluble amyloid aggregates on AD pathogenesis has been the key missing piece of the Alzheimer's puzzle. Data from clinical trials with anti-amyloid agents and recent advances in the diagnosis of AD demonstrate that the driving insult in biologically defined AD is the neurotoxicity of soluble Aβ aggregates, called oligomers and protofibrils, rather than the relatively inert insoluble mature fibrils and amyloid plaques. Amyloid oligomers appear to be the primary factor causing the synaptic impairment, neuronal stress, spreading of tau pathology, and eventual cell death that lead to the clinical syndrome of AD dementia. All other biochemical effects and neurodegenerative changes in the brain that are observed in AD are a response to or a downstream effect of this initial toxic insult by oligomers. Other neurodegenerative disorders follow a similar pattern of pathogenesis, in which normal brain proteins with important biological functions become trapped in the aging brain due to impaired clearance and then misfold and aggregate into neurotoxic species that exhibit prion-like behavior. These aggregates then spread through the brain and cause disease-specific neurodegeneration. Targeting the inhibition of this initial step in neurodegeneration by blocking the misfolding and aggregation of healthy proteins has the potential to slow or arrest disease progression, and if treatment is administered early in the course of AD and other neurodegenerative disorders, it may delay or prevent the onset of clinical symptoms.

From the archives: Inter-organelle communication, strategies to cope with ER stress, and a missing puzzle piece in light-dependent development.

From the archives: Inter-organelle communication, strategies to cope with ER stress, and a missing puzzle piece in light-dependent development.

Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions.

3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGCR) is one of the rate-limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis. It is an integral membrane protein of the endoplasmic reticulum (ER) but has occasionally been described in peroxisomes. By co-immunofluorescence microscopy using different HMGCR antibodies, we present evidence for a dual localization of HMGCR in the ER and peroxisomes in differentiated human monocytic THP-1 cells, primary human monocyte-derived macrophages and human primary skin fibroblasts under conditions of low cholesterol and statin treatment. Using density gradient centrifugation and Western blot analysis, we observed a truncated HMGCR variant of 76 kDa in the peroxisomal fractions, while a full-length HMGCR of 96 kDa was contained in fractions of the ER. In contrast to primary human control fibroblasts, peroxisomal HMGCR was not found in fibroblasts from patients suffering from type-1 rhizomelic chondrodysplasia punctata, who lack functional PEX7 and, thus, cannot import peroxisomal matrix proteins harboring a type-2 peroxisomal targeting signal (PTS2). Moreover, in the N-terminal region of the soluble 76 kDa C-terminal catalytic domain, we identified a PTS2-like motif, which was functional in a reporter context. We propose that under sterol-depleted conditions, part of the soluble HMGCR domain, which is released from the ER by proteolytic processing for further turnover, remains sufficiently long in the cytosol for peroxisomal import via a PTS2/PEX7-dependent mechanism. Altogether, our findings describe a dual localization of HMGCR under combined lipid depletion and statin treatment, adding another puzzle piece to the complex regulation of HMGCR.

The hydrogen life cycle assessment methodology: an overlooked puzzle piece in harmonizing hydrogen certification and trade

The hydrogen life cycle assessment methodology: an overlooked puzzle piece in harmonizing hydrogen certification and trade

Environmental restoration as a reinforcer in ritualistic contexts

AbstractWe conducted a functional analysis of severe problem behavior (aggression, disruption, and self‐injury). The analysis examined four potential socially mediated functions: attention, escape, receipt of tangible items, and restoration of environmental items. Restoration involved the experimenter replacing missing puzzle pieces, ring stacker rings, and shape sorter blocks without giving the items to the participant. An initial multielement functional analysis, followed by a brief pairwise comparison identified restoration of environmental items as the variable maintaining the participant's problem behavior. Subsequently, we conducted brief functional communication training to teach the participant to mand for restoration of disturbed items in the absence of problem behavior.

Nuclear regions as seen with LOFAR international baselines

Context. Radio galaxies dominate the sky at radio wavelengths and represent an essential piece in the galaxy evolution puzzle. High-resolution studies focussed on statistical samples of radio galaxies are expected to shed light on the triggering mechanisms of the active galactic nucleus in their centre, alternating between the phases of activity and quiescence. Aims. For this work, we zoomed in on the sub-arcsec radio structures in the central regions of the 35 radio galaxies in the area covering 6.6 deg2 of the Lockman Hole region. The sources studied here were previously classified as active, remnant, and candidate restarted radio galaxies based on the LOw Frequency ARray (LOFAR) observations at 150 MHz. We examined the morphologies and studied the spectral properties of their central regions to explore their evolutionary stages and to revise the morphological and spectral criteria used to select the initial sample. Methods. We used the newly available LOFAR 150 MHz image obtained using international baselines, yielding a resolution of 0.38″ × 0.30″, making this the first systematic study of the nuclear regions at such a high resolution and low frequency. We used publicly available images from the Faint Images of the Radio Sky at Twenty-cm survey at 1.4 GHz and the Karl G. Jansky Very Large Array (VLA) Sky Survey at 3 GHz to achieve our goals. In addition, for one of the restarted candidates, we present new dedicated observations with the VLA at 3 GHz. Results. We characterised the central regions of the radio galaxies in our sample and found various morphologies, some even mimicking well-known double-double radio galaxies but on a smaller scale, that is, a few tens of kiloparsecs for the size of the restarted activity. We also see the beginnings of active jets or distinct detections unrelated to the large-scale structure. Furthermore, we found a variety of radio spectra characterising the sources in our sample, such as flat, steep, or peaked in the frequency range between 150 MHz and 3 GHz, indicative of the different life-cycle phases of the sources in our sample. Based on these analyses, we confirm five out of six previously considered restarted candidates and identify three more restarted candidates from the active sample. As the number of restarted candidates still exceeds that of remnant candidates, this is consistent with previous results suggesting that the restarted phase can occur after a relatively short remnant phase (i.e. a few tens of millions of years).

Another Piece of the Ionic Liquid's Puzzle: Adsorption of Cl- Ions.

Classical electrochemical and microscopy methods were used to characterize the interfacial processes of the adsorption of chloride ions from ionic liquids at the Bi(111) single crystal electrode. The mixture of 1-ethyl-3-methylimidazolium tetrafluoroborate and 1-ethyl-3-methylimidazolium chloride was electrochemically characterized by using cyclic voltammetry and electrochemical impedance spectroscopy. In situ scanning tunneling microscopy images showed the formation of superstructures at the electrode's surface over an extended period of time. The specific adsorption of chloride ions reaches an equilibrium state in a more viscous ionic liquid medium slower than in aqueous and organic solvents. Capacitance values increase considerably (also depending on alternative current frequency) at the potential region, where the specific adsorption of chloride ions with partial charge transfer occurs.